The system is designed to allow one Mouse and One keyboard to be shared between Two devices You need to connect the Mouse and Keyboard to the Unifying Receiver on each device If you need another mouse and keyboard connected the "other way round" you would need to repeat the link up procedure but you may need to connect with the channels reversed, though I cannot see the point unless you have two people next to each other who can see the both screens and both need access to both devices, although that could be a cause for friction if both parties decide to work on the same screen together - It should work for occasional use for one at a time but not certain