Heck yes!
Okay, this may sound way over the top nerdy, but here is what I do:
I use a PNY Elite V2 1TB thumb drive. Actually, this seems to be a full SSD supporting TRIM and all. Rated to about 550MB/s write, 600MB/s read (if memory serves correctly) but I, like most other owners, have found that the performance actually exceeds the specs. BTW, they now have version 3 which is good for 1,000 MB/s read. It's also small, even smaller than some other thumb drives.
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So, I have 4 partitions on that drive:
1) FAT32, 2GB (Hidden partition). This is a bootable partition to allow for booting on any system (legacy BIOS or UEFI)
2) NTFS, 200GB (Hidden partition). This will hold whatever I want to boot and all my ISO images - more about this below
3) NTFS, BitLocker Encrypted, 600+GB - This is a backup of all my software, important documents, personal photos and videos, my entire digital life!
4) NTFS, 100GB. This a public share so I can pass along data to other people by just handing them my thumb drive.
So, I wrote my own program, similar to Ventoy. On the 2nd partition I have a folder that has any ISO images I might want to boot. All my Windows images, unattended answer files, Macrium Reflect rescue media, etc. are in that folder. When I boot from the thumb drive it will ask me what I want to boot, showing me a list of all the images. I then select what image I want to make bootable and, optionally, what unattended answer file I might want to use. It then preps the drive and when I then reboot and boot from that drive again, it boots that ISO image. So, if I'm on the road with my laptop and it takes a dump, I can boot my Macrium Reflect rescue media or Windows installation image, or anything else I need to recover.
When done, I run a batch file on the thumb drive and it reverts it back to the original state.
Bottom line is that this one drive serves as my rescue disk, a drive I can share data with other people, and storage for all my important stuff protected by BitLocker to go.