I found how to do this using the standard route, but is it doable via regedit too as I have a number of desktops to set this on?
gearupwindows.com
Thanks!

How to Disable "Open File Security Warning" in Windows 11 & 10? | Gear Up Windows
Learn how to disable the "Open File Security Warning" in Windows 11 & 10. Follow our step-by-step guide and bypass the warning message when opening downloaded files from untrusted sources.

Thanks!
My Computer
System One
-
- OS
- Win 11
- Computer type
- PC/Desktop
- CPU
- Ryzen 3600
- Motherboard
- MSI B450 Tomahawk Max
- Memory
- GSkill RipJawz 16Gbx2
- Graphics Card(s)
- GTX960
- Screen Resolution
- 2560x1440
- Hard Drives
- WD750 SSD 1TB
- PSU
- 650w FSP