I assume the only reason that you're considering disabling Microsoft Defender Antivirus is because you are using third party software. If so, you don't have to disable it. You can do periodic scans with it. I did the opposite. I uninstalled my third party AV, because it was just consuming too many resources. I decided to just use MDA. I have Smart App Control enabled, and my main account is a standard user.
My Computer
System One
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- OS
- Windows 11 Pro