With Macrium it's usually best to wait until you get a notification "Updates available" and then do it. Macrium is usually a totally reliable program although for total Disk cloning I go for the Linux DD command as I don't have to worry about any partitioning, file system, efi / mbr issues or "ownership" of file issues. For OS backup and image browsing Free macrium is usually 100% safe and reliable.
Well, I did update thru notification and they pulled update soon after, that happened at least twice. Luckily It didn't affect me as much as some others.